Hi @cmiller16 ,
Do you mean, that because of the spams, it disabled your outlook app on your PC?
Try restarting the outlook app or the PC first and see if you can open it. if everything seems to be no longer working, perhaps reinstalling would be the best way to do it.
Having spams could mean that your email address has been compromised. They can't be stopped but they can be filtered out. If you are using Outlook 2016 or 2019 the Trend Micro Anti Spam Toolbar could help you.
Otherwise, you need to get rid of them manually.
Check this out, see if this can help you: Proven Ways to Get Rid of Annoying Emails | Trend Micro Help Center