Hi @mrayward ,
Since the aforementioned troubleshooting steps that we provided didn't work , you can then proceed in reinstalling the Trend Micro Antivirus app.
You can refer to the link below in using our tool to do the clean uninstallation:
https://helpcenter.trendmicro.com/en-us/article/tmka-18603
After restarting , you can proceed to downloading the installer on the link provided:
https://helpcenter.trendmicro.com/en-us/resources/
After installing again, check the version if 17.8.1121, replicate the issue by opening affected applications/browser, check if improved (Please take note in the PERTS if there's improvement)
After the update to 17.8.1145, check again if the same issue will persist
Let me know if it helps!